Description
Amolife 50 (Amoxapine 50mg)
Amolife 50 (Amoxapine 50mg) is a tricyclic antidepressant prescribed to alleviate symptoms of depression. It works by balancing chemicals in the brain to improve mood and well-being. Typically taken before bedtime due to its sedative effects, Amolife 50 can be consumed with or without food. Always follow your doctor’s instructions for dosage and duration to ensure optimal results and minimize side effects.
Uses Of Amolife 50 (Amoxapine 50mg)
- Treatment of depression
- Treatment of anxiety associated with depression
- Treatment of chronic pain associated with depression
- Treatment of certain sleep disorders related to depression
- Boosting overall energy levels in depressive states
- Treatment of depression: Amolife 50 (Amoxapine 50mg) helps in alleviating the symptoms of depression by regulating the brain’s chemical messengers.
- Treatment of anxiety associated with depression: This medication helps reduce the anxiety that often accompanies depression, providing a sense of calm and well-being.
- Treatment of chronic pain associated with depression: Amolife 50 (Amoxapine 50mg) may alleviate chronic pain symptoms linked to depressive states, improving overall quality of life.
- Treatment of certain sleep disorders related to depression: The sedative effect of Amolife 50 (Amoxapine 50mg) assists in treating insomnia and other sleep issues in depression.
- Boosting overall energy levels in depressive states: By improving mood and reducing anxiety, this medication can enhance energy levels and motivation.
Safety & Precautions
- Avoid alcohol as it may cause excessive drowsiness.
- Consult your doctor before using during pregnancy.
- Use with caution while breastfeeding; consult your doctor.
- Avoid driving if you experience drowsiness or dizziness.
- Inform your doctor about any other medications you are taking.
- Not suitable for sudden discontinuation; follow your doctor’s advice.
- Rise slowly from sitting or lying positions to avoid dizziness.
- Maintain hydration to alleviate dryness in the mouth.
- Monitor weight regularly as weight gain may occur.
- Regularly review your condition with your healthcare provider.
Side Effects
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them.
- Increased heart rate
- Blurred vision
- Orthostatic hypotension (sudden lowering of blood pressure on standing)
- Dryness in mouth
- Abnormality of voluntary movements
- Parkinsonism
- Weight gain
- Akathisia (inability to stay still)
- Dystonia (involuntary muscle contractions)
- Difficulty in urination
- Constipation
- Dizziness
- Sleepiness
- Mood swings
- Nausea
FAQ
Q: How long does it take for Amolife 50 (Amoxapine 50mg) to show its effects?
A: The medication can show a quick response, but it may take a few weeks for you to notice its full effects. It’s important to continue taking it as directed by your doctor and not stop abruptly even if you feel better.
Q: Can I consume alcohol while taking Amolife 50 (Amoxapine 50mg)?
A: It’s best to avoid alcohol as it can enhance drowsiness and other side effects, making it unsafe to perform activities that require mental alertness, such as driving.
Q: What should I do if I miss a dose of Amolife 50 (Amoxapine 50mg)?
A: If you miss a dose, take it as soon as you remember. However, if it’s almost time for your next dose, skip the missed one and continue with your regular schedule. Do not double the dose to catch up.
Q: Is Amolife 50 (Amoxapine 50mg) safe during pregnancy?
A: The safety during pregnancy is not clearly established. It is crucial to consult your doctor who will weigh the benefits and potential risks before prescribing it to you if you are pregnant or planning to conceive.
Q: Can Amolife 50 (Amoxapine 50mg) affect my ability to drive?
A: Yes, this medication can cause drowsiness, dizziness, and blurred vision. These side effects may impair your ability to drive or operate machinery safely. Avoid such activities until you understand how the drug affects you.
Q: Are there any long-term side effects of Amolife 50 (Amoxapine 50mg)?
A: While most side effects are mild and temporary, some may persist. Regular check-ups with your doctor will monitor for any long-term side effects and adjust your treatment as needed to ensure your safety and well-being.
Additional Information
Uses for Amoxapine
Amoxapine, with the chemical composition 2-Chloro-11-(1-piperazinyl)dibenz[b,f][1,4] oxazepine, belongs to the dibenzoxazepine class. It is primarily indicated for the relief of depressive symptoms, including:
- Neurotic or reactive depressive disorders
- Endogenous and psychotic depressions
- Depression with anxiety or agitation
Dosage for Amoxapine
Effective dosage varies from patient to patient. Recommendations are as follows:
- Usual effective dosage: 200 to 300 mg daily
- If no response at 300 mg daily: Increase up to 400 mg depending on tolerance
- Severe cases in hospitalized patients: Up to 600 mg daily in divided doses
Initial Dosage for Adults
The typical starting dosage is:
- 50 mg two or three times daily
- Increase to 100 mg two or three times daily by the end of the first week depending upon tolerance
For effective dosages up to 300 mg, a single daily dose at bedtime is recommended. Increases above 300 mg should only occur if no response is seen after a trial period of at least two weeks.
Elderly Patients
Generally, lower dosages are recommended for elderly patients due to potential sensitivity to the medication:
- Starting dosage: 25 mg two or three times daily
- Possible increase to 50 mg two or three times daily by the end of the first week
Some elderly patients may require up to 150 mg daily, while others may need careful increases up to 300 mg daily based on tolerance and response.
Maintenance
The recommended maintenance dosage is the lowest dose that will maintain remission. If symptoms reappear, increase the dosage to the earlier effective level until symptoms are controlled. For dosages of 300 mg or less, a single dose at bedtime is recommended.
How Supplied
| Strength | Tablet Description | Imprint | Supply Quantity |
|---|---|---|---|
| 25 mg | 8/32″, scored, round, white tablets | DAN 25, 5713 | Bottles of 100 |
| 50 mg | 10/32″, scored, round, orange tablets | DAN 50, 5714 | Bottles of 100 |
| 100 mg | 11/32″, scored, round, blue tablets | DAN 100, 5715 | Bottles of 100 |
| 150 mg | 12/32″, scored, round, orange tablets | DAN 150, 5716 | Bottles of 30 |
Storage
Store at 20-25°C (68-77°F) in a tight container with a child-resistant closure.
Watson Laboratories, Inc., Corona, CA 92880, USA. Revised: August 2007. FDA rev date: 10/23/2002
Overdose Information for Amoxapine
The signs and symptoms of an amoxapine overdose differ significantly from those of other tricyclic antidepressants:
- Frequent CNS effects: Grand mal convulsions, with potential for status epilepticus and coma
- Serious cardiovascular effects are rarely observed
- Renal failure may develop, typically two to five days post-overdose
- Acute tubular necrosis with rhabdomyolysis and myoglobinuria are common renal complications
Treatment
For amoxapine overdose, the following treatments are recommended:
- Induce emesis followed by gastric lavage
- Administer activated charcoal to reduce absorption
- Establish an adequate airway in comatose patients and consider assisted ventilation
- Seizures may respond to standard anticonvulsant therapy like intravenous diazepam or phenytoin
- Treat renal impairment symptomatically
Contraindications for Amoxapine
Amoxapine is contraindicated in patients with:
- Hypersensitivity to dibenzoxazepine compounds
- Concurrent administration of monoamine oxidase inhibitors (MAOIs)
If switching from an MAOI, allow a minimum of 14 days after discontinuation before starting amoxapine, and initiate with caution.
Drug Interactions for Amoxapine
Concurrent use of amoxapine with certain drugs can lead to interactions:
- Enhanced response to alcohol, barbiturates, and other CNS depressants
- Possible increased serum levels of tricyclic antidepressants when co-administered with cimetidine
P450 2D6 Metabolism:
- About 7-10% of Caucasians are poor metabolizers, leading to higher plasma concentrations of TCAs
- Inhibition of P450 2D6 by SSRIs and other drugs can cause toxicity
- Monitor TCA plasma levels when administered with P450 2D6 inhibitors
Therapeutic Interactions
Concurrent electroshock therapy may increase associated hazards. Monitor TCA plasma levels and adjust dosages as necessary during co-therapy.
Clinical Pharmacology for Amoxapine
Amoxapine is rapidly absorbed and peaks in the blood approximately 90 minutes after ingestion. It is almost entirely metabolized, with its primary route of excretion being the kidneys. The serum concentration declines with an eight-hour half-life, and its major metabolite, 8-hydroxyamoxapine, has a 30-hour half-life. Human serum binding is approximately 90%. Studies have shown a more rapid onset of action compared to amitriptyline or imipramine, with clinical effects often observed within 4-7 days, and within two weeks in over 80% of responders.
Supplemental Patient Material
| Condition | Recommended Daily Dosage |
|---|---|
| Initial Dosage for Adults | 50 mg two or three times daily, increased to 100 mg two or three times daily |
| Severe Cases | Up to 600 mg daily in divided doses for hospitalized patients |
| Maintenance Dosage | The lowest dose to maintain remission, often given as a single dose at bedtime |
Mood and Behavior Monitoring
Monitor day-to-day changes, especially during the initial phase of treatment or dose adjustments:
- New or worsening depression
- Emergence of suicidality
- Unusual changes in behavior such as anxiety, agitation, irritability, or panic attacks
Families and caregivers should observe these symptoms and report them immediately to healthcare providers.
