Description
Caverta 100 Tablet (Sildenafil 100mg)
Caverta 100 Tablet (Sildenafil 100mg) is a prescription drug designed to treat erectile dysfunction (impotence) in men. This medication works by enhancing blood flow to the penis, which facilitates achieving and sustaining an erection. As a member of the phosphodiesterase type 5 (PDE 5) inhibitors, Caverta 100 Tablet is effective when taken as directed by a doctor. It has versatile administration options, either on an empty stomach or with food, making it convenient for users. A critical note to remember is that the medicine is beneficial only when the user is sexually stimulated.
Uses Of Caverta 100 Tablet (Sildenafil 100mg)
- Treatment of Erectile Dysfunction
- Treatment of Pulmonary Arterial Hypertension (PAH)
- Treatment of Raynaud’s Phenomenon
- Treatment of High-Altitude Pulmonary Edema (HAPE)
- Treatment of Erectile Dysfunction: Caverta 100 Tablet (Sildenafil 100mg) helps men gain and maintain an erection during sexual activity by increasing the blood flow to the penis.
- Treatment of Pulmonary Arterial Hypertension (PAH): The tablet works by relaxing the blood vessels in the lungs, which can alleviate symptoms and improve exercise capacity in patients suffering from PAH.
- Treatment of Raynaud’s Phenomenon: Sildenafil can help in the relaxation of blood vessels, improving blood flow to extremities affected by Raynaud’s Phenomenon.
- Treatment of High-Altitude Pulmonary Edema (HAPE): Sildenafil may help prevent and treat HAPE by relaxing pulmonary blood vessels, thus decreasing pressure and fluid leakage into the lungs.
Safety & Precautions
- Avoid alcohol while taking this medication.
- Not recommended for use by women.
- Do not use with nitrates (often prescribed for angina).
- Inform your doctor if you have severe heart or liver issues.
- Avoid operating heavy machinery if you feel dizzy.
- Not suitable for individuals who recently experienced a stroke or heart attack.
- Consult your doctor if you have low blood pressure before starting the medication.
- Inform your doctor about any existing kidney conditions.
- Seek medical advice regarding dose adjustments if you have liver disease.
- Keep out of reach of children and store below 30°C.
Side Effects
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them.
- Flushing (sense of warmth in the face, ears, neck, and trunk)
- Headache
- Blurred vision
- Indigestion
- Muscle pain
- Upset stomach
- Rash
- Nasal congestion (stuffy nose)
- Dizziness
- Nausea
- Back pain
- Insomnia
- Chest pain
- Increased heart rate
- Dry mouth
FAQ
1. How should I take Caverta 100 Tablet (Sildenafil 100mg)?
Take Caverta 100 Tablet (Sildenafil 100mg) exactly as prescribed by your doctor. Swallow the tablet whole with a glass of water. It can be taken with or without food, but it’s advisable to take it at a consistent time each day. For optimal results, take the medication about one hour before planned sexual activity.
2. Can I take Caverta 100 Tablet (Sildenafil 100mg) if I’m currently taking other medications?
Before starting Caverta 100 Tablet (Sildenafil 100mg), inform your doctor about all other medications you are taking. Particularly, avoid taking it with nitrates (used for chest pain) or certain other medications as it may lead to severe interactions. Your doctor will guide you based on your health condition and existing medications.
3. How long does Caverta 100 Tablet (Sildenafil 100mg) take to work?
The effectiveness of Caverta 100 Tablet (Sildenafil 100mg) varies from person to person. Generally, it takes about 30 minutes to an hour to start working. Sexual stimulation is required for it to be effective. It’s advisable to take this medicine about an hour before anticipated sexual activity.
4. What should I do if I experience side effects from Caverta 100 Tablet (Sildenafil 100mg)?
If you experience side effects, most of them will be temporary and diminish as your body adjusts. However, if side effects persist or cause significant discomfort, promptly inform your doctor. They may adjust your dose or recommend an alternative treatment to address the issues.
5. Is Caverta 100 Tablet (Sildenafil 100mg) safe for long-term use?
Caverta 100 Tablet (Sildenafil 100mg) is generally safe for long-term use under medical supervision. However, it’s essential to have regular check-ups with your doctor to monitor your health and ensure the medication continues to be effective and safe for you. Do not self-medicate or alter your dosage without consulting your healthcare provider.
6. Can I take Caverta 100 Tablet (Sildenafil 100mg) with food?
Yes, you can take Caverta 100 Tablet (Sildenafil 100mg) with or without food. However, taking it with a high-fat meal may delay its onset of action. If you experience a delay in its effect, consider taking it on an empty stomach to see if that enhances its efficacy.
Additional Information
Dosages of Sildenafil
Sildenafil is available in various forms and strengths. The prescribed dosage may vary based on the condition being treated, patient age, and other health factors. Below is a detailed breakdown of the available dosage forms and the appropriate dosages for different conditions:
| Type | Form | Strength |
|---|---|---|
| Revatio | Tablet | 20 mg |
| Viagra | Tablet | 25 mg, 50 mg, 100 mg |
| Revatio | Injectable Solution | 10 mg/12.5mL |
| Revatio | Oral Suspension | 10 mg/12.5mL (when reconstituted) |
Dosage Considerations for Erectile Dysfunction
- Viagra: 50 mg orally 1 hour before sexual activity.
- This may be increased to 100 mg or reduced to 25 mg based on effectiveness and tolerance.
- Do not exceed 100 mg/day.
Dosage for Pulmonary Arterial Hypertension (PAH)
Oral Administration: Revatio
- 5 mg or 20 mg 3 times daily, administered 4-6 hours apart.
Intravenous (IV) Administration: Revatio
- 2.5 mg or 10 mg bolus 3 times daily if the patient is temporarily unable to take it orally.
- Recommended oral/IV dose should not be exceeded.
- Note: Adding Revatio to bosentan does not provide any beneficial effect on exercise capacity.
Dosing Modifications
- Hepatic Impairment or Severe Renal Impairment: Use an initial dose of 25 mg.
Geriatric Dosing
For Erectile Dysfunction
- Viagra: 25 mg orally initially 1 hour before sexual activity.
- Consider cautious dose selection in elderly due to reduced clearance of sildenafil, resulting in approximately 84% and 107% higher plasma concentrations of sildenafil and its active N-desmethyl metabolite.
- Clinical trials found no significant difference in response between elderly patients and younger adults; however, cautious dose selection should be considered.
For Pulmonary Arterial Hypertension
- Revatio Oral: 5 mg or 20 mg 3 times daily, administered 4-6 hours apart.
- Revatio Intravenous (IV): 2.5 mg or 10 mg bolus 3 times daily if the patient is temporarily unable to take it orally.
- Note: Adding Revatio to bosentan does not provide any beneficial effect on exercise capacity.
Pediatric Dosing
It is not recommended to prescribe sildenafil to children (1-17 years) for pulmonary arterial hypertension (PAH). This recommendation is based on a long-term clinical pediatric trial that showed children taking high doses had a higher risk of death compared to those taking low doses, and low doses were not effective in improving exercise ability.
Drug Interactions
Sildenafil interacts with several other drugs. It is crucial to provide your healthcare provider with a complete list of the medications you are taking to avoid severe complications. Below is a detailed table summarizing severe, moderate, and mild interactions:
| Severity | Drugs |
|---|---|
| Severe | atazanavir, cobicistat, elvitegravir/cobicistat/emtricitabine/tenofovir DF, isosorbide dinitrate, isosorbide mononitrate, nelfinavir, nitroglycerin (IV, PO, rectal, sublingual, topical, transdermal, translingual), ombitasvir/paritaprevir/ritonavir (+/− dasabuvir), riociguat |
| Moderate | carvedilol, epoprostenol, fluvoxamine, labetalol, macitentan, sapropterin |
| Mild | Other phosphodiesterase-5 inhibitors, drugs affecting CYP3A4 |
Always consult with your healthcare provider or pharmacist before starting, stopping, or changing the dosage of any medicine. Keep an updated list of all your medications and share this information with your healthcare provider.
Clinical Studies
Several clinical studies and trials have been done to understand the efficacy and safety profile of sildenafil, particularly in treating erectile dysfunction and pulmonary arterial hypertension. Here are some notable findings:
Erectile Dysfunction (ED)
- Clinical trials have shown that sildenafil significantly improves the ability to achieve and maintain an erection in men with ED compared to a placebo.
- Improvements were noted in patients across various age groups, and the efficacy was maintained over long-term use.
- Sildenafil demonstrated an onset of action within 14 minutes in some patients.
Pulmonary Arterial Hypertension (PAH)
- Controlled trials indicate that sildenafil improves exercise capacity and delays clinical worsening in patients with PAH.
- Patients receiving Revatio experienced a significant increase in the distance they could walk in six minutes compared to those receiving a placebo.
- The combination of Revatio with other PAH treatments like bosentan did not show additional benefits in exercise capacity.
Special Populations
Sildenafil’s efficacy and safety can vary significantly in special populations such as the elderly, patients with severe organ impairments, and pediatric patients. Below is a detailed discussion regarding these populations:
Geriatric Patients
- Due to decreased hepatic, renal, and cardiac function, as well as other comorbid conditions and concomitant pharmacotherapy, the elderly should start on the lower end of the dosing regimen.
- Clinical studies show no significant difference in response between elderly and younger adults, but caution is still advised.
Patients with Renal or Hepatic Impairment
- Patients with severe renal or hepatic impairment should receive an initial dose of 25 mg.
- The pharmacokinetics of sildenafil are altered in these patients, necessitating dosage adjustments to avoid potential side effects.
Pediatric Patients
- Clinical trials indicate increased mortality in pediatric patients treated with high-dose sildenafil for PAH.
- The use of sildenafil in pediatric patients is not recommended due to these risks and the lack of efficacy at low doses.
How to Take Sildenafil
Compliance with your doctor’s instructions is essential when taking sildenafil. Here are some guidelines on how to properly take this medication:
- Oral Tablets: Take the tablet with or without food. However, a high-fat meal may delay the medication’s onset of action.
- Oral Suspension: Shake the bottle well before each dose and measure the liquid form with a proper measuring device.
- Injectable Form: Only healthcare professionals should administer the injectable form in a clinical setting.
- Timing: For erectile dysfunction, take it approximately 1 hour before sexual activity. For PAH, follow the prescribed dosing schedule.
Consulting a Healthcare Provider
Before initiating treatment with sildenafil, discussing your complete medical history with your healthcare provider is imperative. Here are some points to consider:
- Existing Medical Conditions: Make sure to inform your doctor about any cardiovascular issues, liver/kidney impairments, bleeding disorders, or anatomical deformations of the penis.
- Current Medications: Share a list of all the medications, supplements, and herbal products you are currently taking to avoid drug interactions.
- Symptoms and Concerns: Report any symptoms like vision changes, hearing loss, or prolonged erections to your healthcare provider immediately.
In conclusion, sildenafil, available under brand names like Revatio and Viagra, is a potent medication for treating erectile dysfunction and pulmonary arterial hypertension. Its use should be carefully monitored, and dosages should be adjusted based on individual health factors and potential drug interactions. Always consult your healthcare provider for personalized advice and treatment plans.
