Description
Daruvir 800mg Tablet (Darunavir 800mg)
Daruvir 800mg Tablet (Darunavir 800mg) is a potent antiviral medicine specifically designed to treat HIV infection. This medication is effective in stopping the virus from producing new viruses, thereby helping to clear up the infection. To ensure maximum absorption into the body, Daruvir 800mg Tablet (Darunavir 800mg) should be consumed with food. Following the prescribed dose and duration from your doctor is imperative to achieve the best results and avoid the risk of resurgence or worsening of the infection.
Uses Of ‘Daruvir 800mg Tablet (Darunavir 800mg)
- Treatment of HIV infection
- Slows down disease progression
- Improves immune response
- Reduces HIV-related complications
- Enhances the patient’s quality of life
Treatment of HIV infection. Daruvir 800mg Tablet (Darunavir 800mg) is primarily used to decrease the viral load in patients affected by HIV.
Slows down disease progression. By hindering the replication of the virus, it slows the progression of the disease, making it more manageable.
Improves immune response. This medication helps in fortifying the immune system, enabling it to combat infections more effectively.
Reduces HIV-related complications. Regular use of Daruvir 800mg Tablet (Darunavir 800mg) can mitigate complications associated with HIV, such as opportunistic infections.
Enhances the patient’s quality of life. By effectively managing HIV, it enables patients to lead a healthier and longer life.
Safety & Precautions
- Consult your doctor before starting Daruvir 800mg Tablet (Darunavir 800mg).
- Inform your doctor if you are allergic to antibiotics or sulfa drugs.
- Disclose any kidney or liver problems to your doctor.
- Check with your doctor if you have diabetes.
- Do not stop the medication without completing the course.
- Take the tablet with food to enhance absorption.
- Use with caution in elderly patients above 65 years of age.
- Avoid driving if you feel sleepy or dizzy.
- Exercise caution when consuming alcohol with this medication.
- Consult your doctor if you have a history of liver disease, including hepatitis B or C, or hemophilia.
Side Effects
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them.
- Diarrhea
- Hypercholesterolemia (high cholesterol)
- Increased triglyceride level in blood
- Nausea
- Abdominal pain
- Headache
- Vomiting
- Skin rash
- Fatigue
- Mood changes
- Dizziness
- Insomnia
- Muscle pain
- Increased liver enzymes
- Loss of appetite
FAQ
1. How should I take Daruvir 800mg Tablet (Darunavir 800mg)?
Always take Daruvir 800mg Tablet (Darunavir 800mg) exactly as prescribed by your doctor. Swallow the tablet whole with a sufficient amount of water, and make sure to take it with food to enhance absorption. Do not chew, crush, or break the tablet. Consistency is key, so try to take it at the same time each day.
2. Can I stop taking Daruvir 800mg Tablet (Darunavir 800mg) if I start feeling better?
No, you should complete the entire prescribed course even if you start feeling better. Discontinuing the medication prematurely may result in the resurgence or worsening of the infection. Always consult your doctor before making any changes to your medication regimen.
3. Are there any special precautions for elderly patients using Daruvir 800mg Tablet (Darunavir 800mg)?
Yes, elderly patients, particularly those above 65 years of age, should use Daruvir 800mg Tablet (Darunavir 800mg) with caution. It is essential to discuss any pre-existing health conditions and current medications with your doctor to ensure safe and effective treatment.
4. Can I consume alcohol while taking Daruvir 800mg Tablet (Darunavir 800mg)?
Caution is advised when consuming alcohol with Daruvir 800mg Tablet (Darunavir 800mg). Alcohol may interfere with the effectiveness of the medication and exacerbate side effects. It is best to consult your doctor for personalized advice on alcohol consumption while undergoing treatment.
5. What should I do if I miss a dose of Daruvir 800mg Tablet (Darunavir 800mg)?
If you miss a dose of Daruvir 800mg Tablet (Darunavir 800mg), take it as soon as you remember, preferably with food. However, if it is almost time for your next dose, skip the missed dose and resume your regular schedule. Do not double the dose to make up for the missed one.
6. Can Daruvir 800mg Tablet (Darunavir 800mg) be taken during pregnancy and breastfeeding?
Daruvir 800mg Tablet (Darunavir 800mg) is generally considered safe to use during pregnancy and breastfeeding. However, it is crucial to consult your doctor before starting the medication to discuss potential risks and benefits. Limited human data suggest that the drug does not pose significant risks to the baby.
Dosages of Darunavir
Understanding the appropriate dosages for Darunavir is crucial for effective treatment of HIV. Please note that all Darunavir dosages should be taken with ritonavir and food to ensure proper efficacy and absorption.
| Formulation | Dosage |
|---|---|
| Tablet | 75 mg, 150 mg, 400 mg, 600 mg, 800 mg |
| Oral suspension | 100 mg/mL |
Adult Dosage
| Condition | Dosage | Frequency |
|---|---|---|
| HIV Infection (Treatment-naive or antiretroviral treatment-experienced without darunavir resistance-associated substitutions) | 800 mg + ritonavir 100 mg | Once daily with food |
| HIV Infection (Treatment-experienced with at least one darunavir resistance-associated substitution or when genotyping is not obtained) | 600 mg + ritonavir 100 mg | Every 12 hours with food |
| Pregnant Females | 600 mg + ritonavir 100 mg (preferred) or 800 mg + ritonavir 100 mg (alternative) | Every 12 hours/Once daily with food |
Pediatric Dosage
The pediatric dosage of Darunavir varies based on the child’s weight and whether they are treatment-naive or antiretroviral treatment-experienced. Below are the guidelines for pediatric dosing:
- Children below 3 years or below 10 kg: Safety and efficacy not established
- All pediatric dosages must be taken with food
Treatment-naive or antiretroviral treatment-experienced without darunavir resistance-associated substitutions
| Weight | Dosage | Frequency |
|---|---|---|
| 10 kg to below 15 kg (Oral Suspension) |
|
Once daily |
| Above 15 kg to below 30 kg | 600 mg + ritonavir 100 mg | Once daily |
| Above 30 kg to below 40 kg | 675 mg + ritonavir 100 mg | Once daily |
| Above 40 kg | 800 mg + ritonavir 100 mg | Once daily |
Antiretroviral treatment-experienced with at least one darunavir resistance-associated substitution
| Weight | Dosage | Frequency |
|---|---|---|
| 10 kg to below 15 kg (Oral Suspension) |
|
Twice daily |
| Above 15 kg to below 30 kg | 375 mg + ritonavir 48 mg | Twice daily |
| Above 30 kg to below 40 kg | 450 mg + ritonavir 60 mg | Twice daily |
| Above 40 kg | 600 mg + ritonavir 100 mg | Twice daily |
Drug Interactions with Darunavir
Darunavir interacts with numerous other medications which may enhance or reduce its efficacy or increase the risk of adverse effects. It is essential to keep a comprehensive list of all medications you are taking and discuss them with your healthcare provider.
Severe Interactions
- Some antifungals (e.g., voriconazole)
- Antibiotics (e.g., clarithromycin, erythromycin)
- Anticonvulsants (e.g., carbamazepine, phenobarbital, phenytoin)
- Antimycobacterial drugs (e.g., rifampin)
- Antipsychotics (e.g., lurasidone, pimozide)
- Herbal products (e.g., St. John’s Wort)
- HIV drugs (e.g., efavirenz, nevirapine)
Serious Interactions
- Anticoagulants (e.g., warfarin)
- Glucocorticoids (e.g., dexamethasone)
- Atypical antipsychotics (e.g., quetiapine)
- Calcium channel blockers (e.g., diltiazem)
- Benzodiazepines (e.g., diazepam)
Moderate Interactions
For medications with moderate interactions, dose adjustments of Darunavir or the co-administered drugs might be necessary. Consult your healthcare provider for individualized recommendations.
- Oral contraceptives
- Antihistamines
- Antidepressants
Administration Considerations
The administration method of Darunavir could significantly affect its efficacy. Follow your healthcare provider’s instructions precisely, ensuring that the drug is administered with the necessary co-factors or at particular times as noted:
- Always take Darunavir along with ritonavir and food.
- Do not chew, crush, or split Darunavir tablets.
- Use an oral syringe for the suspension form for precise dosing.
- Ensure correct administration for pediatric patients according to weight and age guidelines.
Important Warnings
Certain conditions and factors should be taken into account while considering Darunavir treatment:
- Monitor liver function regularly as Darunavir can cause hepatotoxicity, especially in patients with pre-existing liver conditions.
- Exercise caution in elderly patients due to increased susceptibility to adverse effects.
- Avoid use in children below 3 years of age due to potential toxicity.
Pregnancy and Lactation Guidelines
Darunavir has specific guidelines for pregnant women and those in lactation:
- Preferred dosage in pregnant patients is 600 mg combined with 100 mg of ritonavir taken twice daily.
- 800 mg with ritonavir 100 mg once daily may be considered in specific scenarios where patient compliance or tolerance is an issue.
- HIV-infected mothers are advised not to breastfeed to avoid transmission of the virus to the infant.
Refer to the latest guidelines and consult with healthcare providers for any individualized recommendations and concerns regarding the use of Darunavir. This article is for informational purposes and should not substitute for professional medical advice.
