Description
Decode Age Ca AKG Vegetarian Capsule , Calcium Alpha-Ketoglutarate, Improve Cellular Energy (Calcium Alpha-Keto Glutarate 500mg) is a dietary supplement aimed at enhancing cellular energy and overall vitality. It works by leveraging the potent benefits of Calcium Alpha-Ketoglutarate (Ca AKG), a compound known for its role in cellular metabolism and energy production. This vegetarian capsule is carefully formulated to support those looking to maintain or improve their energy levels through a natural, science-backed approach. Ideal for various age groups, it’s a convenient addition to your daily health regimen.
Uses Of Decode Age Ca AKG Vegetarian Capsule , Calcium Alpha-Ketoglutarate, Improve Cellular Energy (Calcium Alpha-Keto Glutarate 500mg)
- Treatment of fatigue
- Enhancement of athletic performance
- Support for healthy aging
- Boosting mitochondrial function
- Improving cognitive function
Treatment of fatigue. Calcium Alpha-Ketoglutarate helps in rejuvenating tired cells, thereby mitigating symptoms of fatigue.
Enhancement of athletic performance. Athletes can benefit from boosted cellular metabolism for improved performance and recovery.
Support for healthy aging. With its antioxidative properties, it addresses oxidative stress and supports longevity.
Boosting mitochondrial function. Facilitates better cellular energy production at the mitochondrial level.
Improving cognitive function. Supports cognitive health and may aid in reducing brain fog by enhancing cellular processes.
Safety & Precautions
- Consult a healthcare provider before use, especially if you have a medical condition.
- Keep out of reach of children.
- Store in a cool, dry place away from direct sunlight.
- Do not exceed the recommended dosage.
- Not intended for use by pregnant or nursing women.
- Check for potential allergies to ingredients listed on the label.
- Discontinue use and consult a doctor if adverse reactions occur.
- Ensure the bottle is tightly closed after each use.
- Not a substitute for a balanced diet and regular exercise.
- If you are taking other medications, consult your physician before starting this supplement.
Side Effects
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them.
- Nausea
- Headache
- Digestive discomfort
- Fatigue
- Mild skin irritation
- Dry mouth
- Dizziness
- Insomnia
- Palpitations
- Irritability
- Mood swings
- Anxiety
- Allergic reaction (rare)
- Low blood pressure
- Metallic taste in mouth
FAQ
What is Decode Age Ca AKG Vegetarian Capsule , Calcium Alpha-Ketoglutarate, Improve Cellular Energy (Calcium Alpha-Keto Glutarate 500mg) used for?
It is used to enhance cellular energy, support athletic performance, aid in healthy aging, boost mitochondrial function, and improve cognitive function. This supplement is designed to provide a natural boost to your energy levels by supporting your cellular metabolism.
Can I take Decode Age Ca AKG Vegetarian Capsule , Calcium Alpha-Ketoglutarate, Improve Cellular Energy (Calcium Alpha-Keto Glutarate 500mg) if I am pregnant or breastfeeding?
It is not recommended for pregnant or breastfeeding women to take this supplement without first consulting a healthcare provider. Always check with your doctor to understand any potential risks or benefits.
How should I store Decode Age Ca AKG Vegetarian Capsule , Calcium Alpha-Ketoglutarate, Improve Cellular Energy (Calcium Alpha-Keto Glutarate 500mg)?
Store it in a cool, dry place away from direct sunlight. Ensure the bottle is tightly closed after each use to maintain the integrity of the capsules. It’s also best to keep it out of reach of children.
What should I do if I experience side effects from Decode Age Ca AKG Vegetarian Capsule , Calcium Alpha-Ketoglutarate, Improve Cellular Energy (Calcium Alpha-Keto Glutarate 500mg)?
Most side effects are mild and temporary. However, if you experience persisting or worrying symptoms, discontinue use and consult your doctor. Immediate medical attention is necessary if you have a severe allergic reaction.
Can Decode Age Ca AKG Vegetarian Capsule , Calcium Alpha-Ketoglutarate, Improve Cellular Energy (Calcium Alpha-Keto Glutarate 500mg) interact with other medications?
Yes, it may interact with other medications you are currently taking. It is crucial to consult your healthcare provider for personalized advice, especially if you are on medication for chronic conditions or other supplements.
What is the recommended dosage for Decode Age Ca AKG Vegetarian Capsule , Calcium Alpha-Ketoglutarate, Improve Cellular Energy (Calcium Alpha-Keto Glutarate 500mg)?
The recommended dosage will vary depending on individual health goals and conditions. Always follow the dosage instructions provided on the packaging or consult your healthcare provider to determine the appropriate amount for you.
Additional Information: The Impact of Alpha-Ketoglutarate on Aging and Longevity
Recent studies have considerably expanded our understanding of the effects of alpha-ketoglutarate (aKG) on aging and longevity. According to research published in Cell Metabolism, researchers Asadi Shahmirzadi et al. (2020) demonstrated that dietary supplementation with calcium alpha-ketoglutarate (Ca-aKG) results in increased survival and reduced frailty in mice starting from middle-age. These findings support the theory that metabolic pathways influence the biological mechanisms of aging.
Critical Role of aKG in the TCA Cycle
Alpha-ketoglutarate sits at the intersection of carbon and nitrogen metabolism. As an essential metabolite in the tricarboxylic acid (TCA) cycle, aKG is crucial for oxygen-dependent energy derivation and serves as a key player in various catabolic and anabolic pathways.
| Function | Role in TCA Cycle |
|---|---|
| Energy Production | Generates reducing equivalents needed for the electron transport chain |
| Amino Acid Metabolism | Acts as an obligate partner in aminotransferase reactions |
| Chromatin Modification | Participates in reactions involving acetyl-CoA in chromatin dynamics |
| Longevity Regulation | Linked to increased lifespan in model organisms |
Findings on Alpha-Ketoglutarate and Healthspan
The study led by Asadi Shahmirzadi et al. found that aKG supplementation in mice initiated at 18 months led to notable benefits:
- Increased survival
- Compressed period of morbidity
- Reduced frailty
Both male and female mice displayed improvements, but there were notable differences between sexes. Females exhibited significant increases in median and maximal lifespan, while males showed similar trends without achieving statistical significance.
| Sex | Median Lifespan Increase | Maximal Lifespan Increase |
|---|---|---|
| Females | 16.6% | 19.7% |
| Males | 9.6%</ | 12.8% |
Sexual Dimorphism in Response to aKG
Besides survival outcomes, aKG affected inflammatory pathways differently in males and females:
| Response | Females | Males |
|---|---|---|
| Reduction in Frailty Score | 46% | 41% |
| Suppression of Age-Related Increase in Inflammatory Markers | Observed | Not Observed |
Influence of aKG on Inflammation and Immune Response
Interestingly, the male and female mice exhibited variations in their inflammatory responses. The study highlighted the role of aKG in mitigating inflammatory cytokine production and enhancing IL-10 production, a potent anti-inflammatory cytokine.
- aKG-fed females showed a notable reduction in circulating inflammatory cytokines.
- Higher levels of IL-10 were observed in splenic T cells from aKG-treated mice.
Broader Implications for Aging Research
The study by Asadi Shahmirzadi et al. underscores several broader insights relevant to the field of aging:
- Central role of metabolism in aging regulation.
- Sex differences in response to metabolic interventions.
- No associated reduction in body weight or adiposity despite healthspan improvements.
Notably, the study aligns with other research emphasizing the considerable impact of sex on aging biology and longevity regulation, thus indicating potential differences in therapeutic interventions for males and females.
Significance of Frailty Index in Assessing Healthspan
The frailty index used in the study is increasingly recognized as a valuable metric for assessing health during aging. Shifting from merely measuring lifespan to evaluating healthspan provides deeper insights into the quality of life during aging, thus aligning with the objectives of translational research.
| Parameter | Impact of aKG |
|---|---|
| Median Lifespan | Increase in both sexes (significant in females) |
| Maximal Lifespan | Increase in both sexes (significant in females) |
| Frailty Score | Reduction in both sexes |
| Inflammatory Markers | Reduced in females, not males |
Future Research Directions
Considering the promising results of aKG on aging and healthspan, future studies could explore:
- Potential benefits of aKG in nonhuman primates.
- The efficacy of aKG in human clinical trials.
- Elucidation of molecular mechanisms underlying sexual dimorphism in response to aKG.
Conclusion
The comprehensive work by Asadi Shahmirzadi et al. (2020) highlights the significant potential of alpha-ketoglutarate in enhancing healthspan and lifespan, mediated through metabolic and inflammatory pathways. This valuable research paves the way for subsequent studies aimed at improving late-life health and longevity through metabolic interventions.
Citations
- Asadi Shahmirzadi A, Edgar D, Liao C-Y, et al. Alpha-ketoglutarate, an endogenous metabolite, extends lifespan and compresses morbidity in aging mice. Cell Metab. 2020;32:447–456.
- Chin RM, Fu X, Pai MY, et al. The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR. Nature. 2014;510:397–401.
- Hotamisligil GS. Inflammation, metaflammation, and immunometabolic disorders. Nature. 2017;542:177–185.
- Huffman DM, Justice JN, Stout MB, et al. Evaluating health span in preclinical models of aging and disease. J Gerontol A Biol Sci Med Sci. 2016;71:1395–1406.
- Martίnez-Reyes I, Chandel NS. Mitochondrial TCA cycle metabolites control physiology and disease. Nat Commun. 2020;11:102.
- Pietrocola F, Galluzzi L, Bravo-San Pedro JM, et al. Acetyl coenzyme A. Cell Metab. 2015;21:805–821.
- Rhoads TW, Burhans MS, Chen VB, et al. Caloric restriction engages hepatic RNA processing mechanisms in rhesus monkeys. Cell Metab. 2018;27:677-688.e5.
- Sampathkumar NK, Bravo JI, Chen Y, et al. Widespread sex dimorphism in aging and age-related diseases. Hum Genet. 2020;139:333–356.
- Su Y, Wang T, Wu N, et al. Alpha-ketoglutarate extends Drosophila lifespan by inhibiting mTOR and activating AMPK. Aging (Albany N.Y.). 2019;11:4183–4197.
- Tian Q, Zhao J, Yang Q, et al. Dietary alpha-ketoglutarate promotes beige adipogenesis and prevents obesity in middle-aged mice. Aging Cell. 2020;19:e13059.
